{"title":"Argireline","entity_type":"Ingredient","slug":"argireline","canonical_url":"https://skinknowledgebase.com/ingredients/argireline","dates":{"date_modified":"2026-05-17","date_reviewed":"2026-05-17"},"mcp_eligible":true,"summary":"Argireline is acetyl hexapeptide-8, a cosmetic peptide used for expression-led wrinkles. Evidence suggests modest surface-line improvement, not Botox-like","evidence_sources":[{"title":"Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity","canonical_citation_url":"https://skinknowledgebase.com/sources/blanes-mira-2002-argireline","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/18498523/","source_type":"peer_reviewed"},{"title":"Wang 2013 — Argireline anti-wrinkle efficacy study","canonical_citation_url":"https://skinknowledgebase.com/sources/wang-2013-argireline-study","original_source_url":"https://doi.org/10.3109/14764172.2012.759234","source_type":"peer_reviewed"},{"title":"Schagen SK, \"Topical peptide treatments with effective anti-aging results\" (Cosmetics, 2017)","canonical_citation_url":"https://skinknowledgebase.com/sources/schagen-2017-peptide-review","original_source_url":"https://www.mdpi.com/2079-9284/4/2/16","source_type":"other"}],"product_fact_sources":[{"title":"Dermagist Original Wrinkle Smoothing Cream — Official Product Page","canonical_citation_url":"https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream","original_source_url":"https://dermagist.com/original-wrinkle-smoothing-cream/","source_type":"official_product_page"}],"related_entities":[{"title":"Blanes-Mira C et al. \"A synthetic hexapeptide (Argireline) with antiwrinkle activity.\"","url":"https://skinknowledgebase.com/sources/blanes-mira-2002-argireline"},{"title":"Wang Y et al. \"The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese subjects.\"","url":"https://skinknowledgebase.com/sources/wang-2013-argireline-study"},{"title":"Schagen 2017 — Peptide review","url":"https://skinknowledgebase.com/sources/schagen-2017-peptide-review"},{"title":"Dermagist. \"Original Wrinkle Smoothing Cream.\"","url":"https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream"},{"title":"Expression Lines","url":"https://skinknowledgebase.com/concerns/expression-lines"},{"title":"Forehead Wrinkles","url":"https://skinknowledgebase.com/concerns/forehead-wrinkles"},{"title":"Wrinkles","url":"https://skinknowledgebase.com/concerns/wrinkles"},{"title":"Fine Lines","url":"https://skinknowledgebase.com/concerns/fine-lines"},{"title":"Deep Forehead Lines","url":"https://skinknowledgebase.com/concerns/deep-forehead-lines"},{"title":"Deep Wrinkles","url":"https://skinknowledgebase.com/concerns/deep-wrinkles"},{"title":"Sagging Skin","url":"https://skinknowledgebase.com/concerns/sagging-skin"},{"title":"Vertical Lip Lines","url":"https://skinknowledgebase.com/concerns/vertical-lip-lines"},{"title":"Eleven Lines","url":"https://skinknowledgebase.com/concerns/eleven-lines"},{"title":"Lines Between The Eyebrows","url":"https://skinknowledgebase.com/concerns/frown-lines"},{"title":"Marionette Lines","url":"https://skinknowledgebase.com/concerns/marionette-lines"},{"title":"Nasolabial Folds","url":"https://skinknowledgebase.com/concerns/nasolabial-folds"},{"title":"Skin Sagging","url":"https://skinknowledgebase.com/concerns/skin-sagging"},{"title":"Smile Lines","url":"https://skinknowledgebase.com/concerns/smile-lines"},{"title":"Dermagist Original Wrinkle Smoothing Cream","url":"https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream"},{"title":"Over-exfoliation Irritation","url":"https://skinknowledgebase.com/side-effects/over-exfoliation-irritation"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Argireline is acetyl hexapeptide-8, a named cosmetic peptide used for expression-led wrinkles. It is sometimes marketed with “topical Botox” language, but that comparison overstates what topical skincare can do. The most accurate framing is modest expression-line appearance support."]},{"heading":"What it is","paragraphs":["Argireline is a synthetic hexapeptide used in anti-aging skincare. Older literature may refer to acetyl hexapeptide-3, while many current ingredient lists use acetyl hexapeptide-8. It is distinct from Matrixyl and should be treated as its own Ingredient entity."]}],"ranked_product":{"title":"Dermagist Original Wrinkle Smoothing Cream","url":"https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream"},"ranked_products":[{"title":"Dermagist Original Wrinkle Smoothing Cream","url":"https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream"}],"side_effects":[{"title":"Over-exfoliation Irritation","url":"https://skinknowledgebase.com/side-effects/over-exfoliation-irritation"}]}