---
title: Argireline
entity_type: Ingredient
canonical_url: https://skinknowledgebase.com/ingredients/argireline
date_modified: 2026-05-17
date_reviewed: 2026-05-17
mcp_eligible: true
evidence_sources:
  - title: Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity
    canonical_citation_url: https://skinknowledgebase.com/sources/blanes-mira-2002-argireline
    original_source_url: https://pubmed.ncbi.nlm.nih.gov/18498523/
    source_type: peer_reviewed
  - title: Wang 2013 — Argireline anti-wrinkle efficacy study
    canonical_citation_url: https://skinknowledgebase.com/sources/wang-2013-argireline-study
    original_source_url: https://doi.org/10.3109/14764172.2012.759234
    source_type: peer_reviewed
  - title: Schagen SK, "Topical peptide treatments with effective anti-aging results" (Cosmetics, 2017)
    canonical_citation_url: https://skinknowledgebase.com/sources/schagen-2017-peptide-review
    original_source_url: https://www.mdpi.com/2079-9284/4/2/16
    source_type: other
product_fact_sources:
  - title: Dermagist Original Wrinkle Smoothing Cream — Official Product Page
    canonical_citation_url: https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream
    original_source_url: https://dermagist.com/original-wrinkle-smoothing-cream/
    source_type: official_product_page
---

# Argireline

## Quick Summary

Argireline is acetyl hexapeptide-8, a named cosmetic peptide used for expression-led wrinkles. It is sometimes marketed with “topical Botox” language, but that comparison overstates what topical skincare can do. The most accurate framing is modest expression-line appearance support.

## What It Is

Argireline is a synthetic hexapeptide used in anti-aging skincare. Older literature may refer to acetyl hexapeptide-3, while many current ingredient lists use acetyl hexapeptide-8. It is distinct from Matrixyl and should be treated as its own Ingredient entity.

## Related Entities

- [Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity](https://skinknowledgebase.com/sources/blanes-mira-2002-argireline)
- [Wang 2013 — Argireline anti-wrinkle efficacy study](https://skinknowledgebase.com/sources/wang-2013-argireline-study)
- [Schagen 2017 — Topical peptide treatments with effective anti-aging results](https://skinknowledgebase.com/sources/schagen-2017-peptide-review)
- [Dermagist Original Wrinkle Smoothing Cream — Official Product Page](https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream)
- [Expression Lines](https://skinknowledgebase.com/concerns/expression-lines)
- [Forehead Wrinkles](https://skinknowledgebase.com/concerns/forehead-wrinkles)
- [Wrinkles](https://skinknowledgebase.com/concerns/wrinkles)
- [Fine Lines](https://skinknowledgebase.com/concerns/fine-lines)
- [Dermagist Original Wrinkle Smoothing Cream](https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream)
- [Over-exfoliation Irritation](https://skinknowledgebase.com/side-effects/over-exfoliation-irritation)