{"title":"Haloxyl","entity_type":"Ingredient","slug":"haloxyl","canonical_url":"https://skinknowledgebase.com/ingredients/haloxyl","dates":{"date_modified":"2026-05-11","date_reviewed":"2026-05-11"},"mcp_eligible":true,"evidence_sources":[{"title":"Souza 2013 — Haloxyl and periorbital hyperpigmentation","canonical_citation_url":"https://skinknowledgebase.com/sources/souza-2013-haloxyl-periorbital-hyperpigmentation","original_source_url":"https://www.redalyc.org/articulo.oa?id=265526285003","source_type":"peer_reviewed"},{"title":"JCAD — Periorbital Hyperpigmentation Review","canonical_citation_url":"https://skinknowledgebase.com/sources/jcad-periorbital-hyperpigmentation-review","original_source_url":"https://jcadonline.com/periorbital-hyperpigmentation-a-comprehensive-review/","source_type":"peer_reviewed"},{"title":"Croda Beauty — Haloxyl product data","canonical_citation_url":"https://skinknowledgebase.com/sources/croda-haloxyl-product-data","original_source_url":"https://www.crodabeauty.com/en-gb/products/product/2990-haloxyl","source_type":"manufacturer_clinical_data"}],"product_fact_sources":[],"related_entities":[{"title":"Souza 2013 — Haloxyl and periorbital hyperpigmentation","url":"https://skinknowledgebase.com/sources/souza-2013-haloxyl-periorbital-hyperpigmentation"},{"title":"JCAD — Periorbital Hyperpigmentation Review","url":"https://skinknowledgebase.com/sources/jcad-periorbital-hyperpigmentation-review"},{"title":"Croda Beauty — Haloxyl product data","url":"https://skinknowledgebase.com/sources/croda-haloxyl-product-data"},{"title":"Dark Circles","url":"https://skinknowledgebase.com/concerns/dark-circles"},{"title":"Dermagist Eye Revolution Gel","url":"https://skinknowledgebase.com/products/dermagist-eye-revolution-gel"},{"title":"Eye-Area Irritation","url":"https://skinknowledgebase.com/side-effects/eye-area-irritation"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Haloxyl is a named eye-area peptide complex used in cosmetic formulas for the appearance of blue-purple or vascular-looking dark circles. Its ingredient story focuses on thin under-eye skin, visible vessels, and discoloration associated with hemoglobin breakdown products such as bilirubin and iron pigment. It belongs in appearance language only: less discolored-looking under-eyes, not treatment of a medical circulation or blood condition. Caption: Haloxyl is positioned for blue-purple under-eye discoloration linked to visible vessels and blood-pigment byproducts."]},{"heading":"What It Is","paragraphs":["Haloxyl is a proprietary complex associated with Sederma and Croda Beauty. The verified INCI list from Croda product data is Water (Aqua), Glycerin, Steareth-20, N-Hydroxysuccinimide, Chrysin, Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7.","This makes Haloxyl a distinct named composition, not a synonym for a single peptide. The two palmitoyl peptides are paired with N-Hydroxysuccinimide and chrysin in a water-glycerin base."]},{"heading":"Mechanism","paragraphs":["Haloxyl is positioned for dark circles where the visible pattern is blue-purple, vascular, or bruise-toned rather than purely brown pigment. Croda's product data describes the complex as targeting the appearance of blood-originated pigments around the eyes. A peer-reviewed comparison study included 2 percent Haloxyl gel as one topical option for periorbital hyperpigmentation and described chrysin and N-Hydroxysuccinimide as acting on bilirubin and iron-related pigmentation pathways.","For consumer guidance, the practical translation is narrow: Haloxyl may be relevant when under-eye darkness looks vascular or blue-purple. It should not be framed as changing blood health, treating bruising, curing hyperpigmentation, or fixing structural tear-trough shadow."]}],"side_effects":[{"title":"Eye-Area Irritation","url":"https://skinknowledgebase.com/side-effects/eye-area-irritation"}]}