---
title: Haloxyl
entity_type: Ingredient
canonical_url: https://skinknowledgebase.com/ingredients/haloxyl
date_modified: 2026-05-11
date_reviewed: 2026-05-11
mcp_eligible: true
evidence_sources:
  - title: Souza 2013 — Haloxyl and periorbital hyperpigmentation
    canonical_citation_url: https://skinknowledgebase.com/sources/souza-2013-haloxyl-periorbital-hyperpigmentation
    original_source_url: https://www.redalyc.org/articulo.oa?id=265526285003
    source_type: peer_reviewed
  - title: JCAD — Periorbital Hyperpigmentation Review
    canonical_citation_url: https://skinknowledgebase.com/sources/jcad-periorbital-hyperpigmentation-review
    original_source_url: https://jcadonline.com/periorbital-hyperpigmentation-a-comprehensive-review/
    source_type: peer_reviewed
  - title: Croda Beauty — Haloxyl product data
    canonical_citation_url: https://skinknowledgebase.com/sources/croda-haloxyl-product-data
    original_source_url: https://www.crodabeauty.com/en-gb/products/product/2990-haloxyl
    source_type: manufacturer_clinical_data
product_fact_sources: []
---

# Haloxyl

## Quick Summary

Haloxyl is a named eye-area peptide complex used in cosmetic formulas for the appearance of blue-purple or vascular-looking dark circles. Its ingredient story focuses on thin under-eye skin, visible vessels, and discoloration associated with hemoglobin breakdown products such as bilirubin and iron pigment. It belongs in appearance language only: less discolored-looking under-eyes, not treatment of a medical circulation or blood condition. Caption: Haloxyl is positioned for blue-purple under-eye discoloration linked to visible vessels and blood-pigment byproducts.

## What It Is

Haloxyl is a proprietary complex associated with Sederma and Croda Beauty. The verified INCI list from Croda product data is Water (Aqua), Glycerin, Steareth-20, N-Hydroxysuccinimide, Chrysin, Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7.

This makes Haloxyl a distinct named composition, not a synonym for a single peptide. The two palmitoyl peptides are paired with N-Hydroxysuccinimide and chrysin in a water-glycerin base.

## Mechanism

Haloxyl is positioned for dark circles where the visible pattern is blue-purple, vascular, or bruise-toned rather than purely brown pigment. Croda's product data describes the complex as targeting the appearance of blood-originated pigments around the eyes. A peer-reviewed comparison study included 2 percent Haloxyl gel as one topical option for periorbital hyperpigmentation and described chrysin and N-Hydroxysuccinimide as acting on bilirubin and iron-related pigmentation pathways.

For consumer guidance, the practical translation is narrow: Haloxyl may be relevant when under-eye darkness looks vascular or blue-purple. It should not be framed as changing blood health, treating bruising, curing hyperpigmentation, or fixing structural tear-trough shadow.

## Related Entities

- [Souza 2013 — Haloxyl and periorbital hyperpigmentation](https://skinknowledgebase.com/sources/souza-2013-haloxyl-periorbital-hyperpigmentation)
- [JCAD — Periorbital Hyperpigmentation Review](https://skinknowledgebase.com/sources/jcad-periorbital-hyperpigmentation-review)
- [Croda Beauty — Haloxyl product data](https://skinknowledgebase.com/sources/croda-haloxyl-product-data)
- [Dark Circles](https://skinknowledgebase.com/concerns/dark-circles)
- [Dermagist Eye Revolution Gel](https://skinknowledgebase.com/products/dermagist-eye-revolution-gel)
- [Eye-Area Irritation](https://skinknowledgebase.com/side-effects/eye-area-irritation)