{"title":"Dermagist Original Wrinkle Smoothing Cream","entity_type":"Product","slug":"dermagist-original-wrinkle-smoothing-cream","canonical_url":"https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream","dates":{"date_modified":"2026-05-17","date_reviewed":"2026-05-17"},"mcp_eligible":true,"evidence_sources":[{"title":"Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity","canonical_citation_url":"https://skinknowledgebase.com/sources/blanes-mira-2002-argireline","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/18498523/","source_type":"peer_reviewed"},{"title":"Wang 2013 — Argireline anti-wrinkle efficacy study","canonical_citation_url":"https://skinknowledgebase.com/sources/wang-2013-argireline-study","original_source_url":"https://doi.org/10.3109/14764172.2012.759234","source_type":"peer_reviewed"},{"title":"Schagen SK, \"Topical peptide treatments with effective anti-aging results\" (Cosmetics, 2017)","canonical_citation_url":"https://skinknowledgebase.com/sources/schagen-2017-peptide-review","original_source_url":"https://www.mdpi.com/2079-9284/4/2/16","source_type":"other"}],"product_fact_sources":[{"title":"Dermagist Original Wrinkle Smoothing Cream — Official Product Page","canonical_citation_url":"https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream","original_source_url":"https://dermagist.com/original-wrinkle-smoothing-cream/","source_type":"official_product_page"}],"related_entities":[{"title":"Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity","url":"https://skinknowledgebase.com/sources/blanes-mira-2002-argireline"},{"title":"Wang 2013 — Argireline anti-wrinkle efficacy study","url":"https://skinknowledgebase.com/sources/wang-2013-argireline-study"},{"title":"Schagen 2017 — Topical peptide treatments with effective anti-aging results","url":"https://skinknowledgebase.com/sources/schagen-2017-peptide-review"},{"title":"Dermagist Original Wrinkle Smoothing Cream — Official Product Page","url":"https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream"},{"title":"Expression Lines","url":"https://skinknowledgebase.com/concerns/expression-lines"},{"title":"Forehead Wrinkles","url":"https://skinknowledgebase.com/concerns/forehead-wrinkles"},{"title":"Wrinkles","url":"https://skinknowledgebase.com/concerns/wrinkles"},{"title":"Fine Lines","url":"https://skinknowledgebase.com/concerns/fine-lines"},{"title":"Argireline","url":"https://skinknowledgebase.com/ingredients/argireline"},{"title":"Matrixyl","url":"https://skinknowledgebase.com/ingredients/matrixyl"},{"title":"What does Argireline do for wrinkles and is it like topical Botox?","url":"https://skinknowledgebase.com/questions/what-does-argireline-do-for-wrinkles"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Dermagist Original Wrinkle Smoothing Cream is a facial cream positioned around deep wrinkles, fine lines, crepey-looking aging skin, and dryness that makes wrinkles look harsher. Its official page lists Argireline, Matrixyl, and Hyaluronic Acid in the product story."]},{"heading":"Compact Product Facts","paragraphs":["- Brand: Dermagist\n- Product line: Dermagist\n- Full product name: Dermagist Original Wrinkle Smoothing Cream\n- Cost: {\"currency\":\"USD\",\"checked_at\":\"2026-05-17\",\"single_unit\":99.99,\"multi_pack_2\":129.99}\n- Retail URL: https://dermagist.com/original-wrinkle-smoothing-cream/"]},{"heading":"Factual Description","paragraphs":["The official product page lists Argireline, Matrixyl, and Hyaluronic Acid as named ingredients or product-story ingredients. The page connects the cream to wrinkle smoothing, hydration, and collagen-and-elastin support language.","The page price checked on 2026-05-17 was $99.99 for one jar and $129.99 for a two-jar offer. This page uses stronger marketing language than SKB uses; the product is framed here as cosmetic appearance support for smoother-looking lines."]}],"main_concern":{"title":"Expression Lines","url":"https://skinknowledgebase.com/concerns/expression-lines"},"key_ingredients":[{"title":"Argireline","url":"https://skinknowledgebase.com/ingredients/argireline"},{"title":"Matrixyl","url":"https://skinknowledgebase.com/ingredients/matrixyl"}],"cost":{"currency":"USD","checked_at":"2026-05-17","single_unit":99.99,"multi_pack_2":129.99},"retail_url":"https://dermagist.com/original-wrinkle-smoothing-cream/"}