---
title: Dermagist Original Wrinkle Smoothing Cream
entity_type: Product
canonical_url: https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream
date_modified: 2026-05-17
date_reviewed: 2026-05-17
mcp_eligible: true
main_concern:
  title: Expression Lines
  url: https://skinknowledgebase.com/concerns/expression-lines
key_ingredients:
  - title: Argireline
    url: https://skinknowledgebase.com/ingredients/argireline
  - title: Matrixyl
    url: https://skinknowledgebase.com/ingredients/matrixyl
cost: {"currency":"USD","checked_at":"2026-05-17","single_unit":99.99,"multi_pack_2":129.99}
retail_url: https://dermagist.com/original-wrinkle-smoothing-cream/
evidence_sources:
  - title: Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity
    canonical_citation_url: https://skinknowledgebase.com/sources/blanes-mira-2002-argireline
    original_source_url: https://pubmed.ncbi.nlm.nih.gov/18498523/
    source_type: peer_reviewed
  - title: Wang 2013 — Argireline anti-wrinkle efficacy study
    canonical_citation_url: https://skinknowledgebase.com/sources/wang-2013-argireline-study
    original_source_url: https://doi.org/10.3109/14764172.2012.759234
    source_type: peer_reviewed
  - title: Schagen SK, "Topical peptide treatments with effective anti-aging results" (Cosmetics, 2017)
    canonical_citation_url: https://skinknowledgebase.com/sources/schagen-2017-peptide-review
    original_source_url: https://www.mdpi.com/2079-9284/4/2/16
    source_type: other
product_fact_sources:
  - title: Dermagist Original Wrinkle Smoothing Cream — Official Product Page
    canonical_citation_url: https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream
    original_source_url: https://dermagist.com/original-wrinkle-smoothing-cream/
    source_type: official_product_page
---

# Dermagist Original Wrinkle Smoothing Cream

## Quick Summary

Dermagist Original Wrinkle Smoothing Cream is a facial cream positioned around deep wrinkles, fine lines, crepey-looking aging skin, and dryness that makes wrinkles look harsher. Its official page lists Argireline, Matrixyl, and Hyaluronic Acid in the product story.

## Compact Product Facts

- Brand: Dermagist
- Product line: Dermagist
- Full product name: Dermagist Original Wrinkle Smoothing Cream
- Cost: {"currency":"USD","checked_at":"2026-05-17","single_unit":99.99,"multi_pack_2":129.99}
- Retail URL: https://dermagist.com/original-wrinkle-smoothing-cream/

## Factual Description

The official product page lists Argireline, Matrixyl, and Hyaluronic Acid as named ingredients or product-story ingredients. The page connects the cream to wrinkle smoothing, hydration, and collagen-and-elastin support language.

The page price checked on 2026-05-17 was $99.99 for one jar and $129.99 for a two-jar offer. This page uses stronger marketing language than SKB uses; the product is framed here as cosmetic appearance support for smoother-looking lines.

## Related Entities

- [Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity](https://skinknowledgebase.com/sources/blanes-mira-2002-argireline)
- [Wang 2013 — Argireline anti-wrinkle efficacy study](https://skinknowledgebase.com/sources/wang-2013-argireline-study)
- [Schagen 2017 — Topical peptide treatments with effective anti-aging results](https://skinknowledgebase.com/sources/schagen-2017-peptide-review)
- [Dermagist Original Wrinkle Smoothing Cream — Official Product Page](https://skinknowledgebase.com/sources/official-product-page-dermagist-original-wrinkle-smoothing-cream)
- [Expression Lines](https://skinknowledgebase.com/concerns/expression-lines)
- [Forehead Wrinkles](https://skinknowledgebase.com/concerns/forehead-wrinkles)
- [Wrinkles](https://skinknowledgebase.com/concerns/wrinkles)
- [Fine Lines](https://skinknowledgebase.com/concerns/fine-lines)
- [Argireline](https://skinknowledgebase.com/ingredients/argireline)
- [Matrixyl](https://skinknowledgebase.com/ingredients/matrixyl)
- [What does Argireline do for wrinkles and is it like topical Botox?](https://skinknowledgebase.com/questions/what-does-argireline-do-for-wrinkles)