---
title: Differin Gel — Adapalene 0.1% Acne Treatment
entity_type: Product
canonical_url: https://skinknowledgebase.com/products/differin-gel-adapalene
date_modified: 2026-05-10
date_reviewed: 2026-05-10
mcp_eligible: true
main_concern:
  title: Blackheads
  url: https://skinknowledgebase.com/concerns/blackheads
key_ingredients:
  - title: Adapalene
    url: https://skinknowledgebase.com/ingredients/adapalene
cost: {"currency":"USD","checked_at":"2026-05-10","single_unit":14.99,"multi_pack_2":24.99}
retail_url: https://differin.com/shop/differin-gel/3029949.html
evidence_sources:
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    canonical_citation_url: https://skinknowledgebase.com/sources/aad-acne-diagnosis-treatment
    original_source_url: https://www.aad.org/public/diseases/acne/derm-treat/treat
    source_type: medical_reference
  - title: DermNet NZ — Topical retinoids
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    original_source_url: https://dermnetnz.org/topics/topical-retinoids
    source_type: medical_reference
  - title: Liu 2020 — Cochrane topical acne review
    canonical_citation_url: https://skinknowledgebase.com/sources/liu-2020-cochrane-topical-acne
    original_source_url: https://pubmed.ncbi.nlm.nih.gov/32356369/
    source_type: peer_reviewed
product_fact_sources:
  - title: Differin — Official Differin Gel product page
    canonical_citation_url: https://skinknowledgebase.com/sources/official-product-page-differin-gel-adapalene
    original_source_url: https://differin.com/shop/differin-gel/3029949.html
    source_type: official_product_page
---

# Differin Gel — Adapalene 0.1% Acne Treatment

## Quick Summary

Differin Gel — Adapalene 0.1% Acne Treatment is a OTC adapalene gel. it is the Ranked Product because it centers one active, adapalene, with a mechanism that maps directly to blackhead-prone pores and comedone formation. The product is positioned here for the cosmetic appearance of fewer visible blackheads and smoother-looking pores over time, not as a guarantee of individual results or as medical advice.

## Compact Product Facts

- Brand: Differin
- Product line: Differin Gel
- Full product name: Differin Gel — Adapalene 0.1% Acne Treatment
- Cost: {"currency":"USD","checked_at":"2026-05-10","single_unit":14.99,"multi_pack_2":24.99}
- Retail URL: https://differin.com/shop/differin-gel/3029949.html

## Factual Description

Differin Gel is a mass-retail OTC adapalene 0.1% gel. The active ingredient is Adapalene, a topical retinoid that supports more regular follicular turnover. That makes it a direct fit for blackhead-prone pores, where visible dark dots begin as comedone plugs inside the follicle.

This Product page is a factual catalog page. It is not a review, an endorsement, or a promise that the product will work the same way for every user. The ingredient mechanism and tolerability context are summarized on the linked Ingredient, Concern, Side Effect, and Source pages.

## Related Entities

- [AAD — Acne: Diagnosis and treatment](https://skinknowledgebase.com/sources/aad-acne-diagnosis-treatment)
- [DermNet NZ — Topical retinoids](https://skinknowledgebase.com/sources/dermnet-topical-retinoids)
- [Liu 2020 — Cochrane topical acne review](https://skinknowledgebase.com/sources/liu-2020-cochrane-topical-acne)
- [Differin — Official Differin Gel product page](https://skinknowledgebase.com/sources/official-product-page-differin-gel-adapalene)
- [Blackheads](https://skinknowledgebase.com/concerns/blackheads)
- [Adapalene](https://skinknowledgebase.com/ingredients/adapalene)
- [How do I get rid of blackheads on my nose?](https://skinknowledgebase.com/questions/how-do-i-get-rid-of-blackheads-on-my-nose)
- [What causes adult acne and how do I treat it?](https://skinknowledgebase.com/questions/what-causes-adult-acne)
- [Adult Acne](https://skinknowledgebase.com/concerns/adult-acne)