{"title":"PubMed — Niacinamide and hyperpigmented spots","entity_type":"Source","slug":"bissett-2004-niacinamide-aging-facial-skin","canonical_url":"https://skinknowledgebase.com/sources/bissett-2004-niacinamide-aging-facial-skin","dates":{"date_modified":"2026-05-11","date_reviewed":"2026-05-11"},"mcp_eligible":true,"evidence_sources":[],"product_fact_sources":[],"related_entities":[{"title":"The Ordinary Niacinamide 10% + Zinc 1% Oil Control Serum","url":"https://skinknowledgebase.com/products/the-ordinary-niacinamide-10-zinc-1-serum"},{"title":"CeraVe Eye Repair Cream","url":"https://skinknowledgebase.com/products/cerave-eye-repair-cream"},{"title":"Niacinamide","url":"https://skinknowledgebase.com/ingredients/niacinamide"},{"title":"Dermagist Acne Scars Fading Cream","url":"https://skinknowledgebase.com/products/dermagist-acne-scars-fading-cream"},{"title":"What is niacinamide good for and how do I use it?","url":"https://skinknowledgebase.com/questions/what-is-niacinamide-good-for"},{"title":"Dark Circles","url":"https://skinknowledgebase.com/concerns/dark-circles"},{"title":"Dark Spots from Acne","url":"https://skinknowledgebase.com/concerns/dark-spots-from-acne"},{"title":"How do I fade dark spots left from acne?","url":"https://skinknowledgebase.com/questions/how-do-i-fade-dark-acne-scars"},{"title":"How do I get rid of dark circles under my eyes?","url":"https://skinknowledgebase.com/questions/how-do-i-get-rid-of-dark-circles-under-my-eyes"},{"title":"What causes dull skin and how do I get a glow?","url":"https://skinknowledgebase.com/questions/what-causes-dull-skin-and-how-do-i-get-a-glow"},{"title":"Facial Hyperpigmentation","url":"https://skinknowledgebase.com/concerns/facial-hyperpigmentation"},{"title":"How do I shrink large pores on my face?","url":"https://skinknowledgebase.com/questions/how-do-i-shrink-large-pores-on-my-face"},{"title":"How do I fade dark patches on my face?","url":"https://skinknowledgebase.com/questions/how-do-i-fade-dark-patches-on-my-face"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Peer-reviewed niacinamide study supporting uneven tone and hyperpigmented-spot appearance context."]},{"heading":"What Studied","paragraphs":["Study of topical niacinamide in aging facial skin."]},{"heading":"Main Findings","paragraphs":["The source supports appearance-focused discussion of niacinamide and hyperpigmented spots."]},{"heading":"Why It Matters","paragraphs":["This source supports Niacinamide as a tone-supporting ingredient."]}],"source_type":"other","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/18492135/"}