---
title: PubMed — Niacinamide and hyperpigmented spots
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/bissett-2004-niacinamide-aging-facial-skin
date_modified: 2026-05-11
date_reviewed: 2026-05-11
mcp_eligible: true
source_type: other
original_source_url: https://pubmed.ncbi.nlm.nih.gov/18492135/
evidence_sources: []
product_fact_sources: []
---

# PubMed — Niacinamide and hyperpigmented spots

## Quick Summary

Peer-reviewed niacinamide study supporting uneven tone and hyperpigmented-spot appearance context.

## What Studied

Study of topical niacinamide in aging facial skin.

## Main Findings

The source supports appearance-focused discussion of niacinamide and hyperpigmented spots.

## Why It Matters

This source supports Niacinamide as a tone-supporting ingredient.

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