{"title":"Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity","entity_type":"Source","slug":"blanes-mira-2002-argireline","canonical_url":"https://skinknowledgebase.com/sources/blanes-mira-2002-argireline","dates":{"date_modified":"2026-05-17","date_reviewed":"2026-05-17"},"mcp_eligible":true,"evidence_sources":[],"product_fact_sources":[],"related_entities":[{"title":"Expression Lines","url":"https://skinknowledgebase.com/concerns/expression-lines"},{"title":"Forehead Wrinkles","url":"https://skinknowledgebase.com/concerns/forehead-wrinkles"},{"title":"What does Argireline do for wrinkles and is it like topical Botox?","url":"https://skinknowledgebase.com/questions/what-does-argireline-do-for-wrinkles"},{"title":"Argireline","url":"https://skinknowledgebase.com/ingredients/argireline"},{"title":"Dermagist Original Wrinkle Smoothing Cream","url":"https://skinknowledgebase.com/products/dermagist-original-wrinkle-smoothing-cream"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Foundational Argireline paper describing acetyl hexapeptide-3, proposed SNARE-complex interference, and a small topical wrinkle-depth study."]},{"heading":"What Studied","paragraphs":["Reference used for Argireline, peptide, wrinkle, or product-fact context in this cosmetic skincare page."]},{"heading":"Main Findings","paragraphs":["The source supports cautious appearance-focused language and does not justify injectable-equivalent claims for topical Argireline skincare."]},{"heading":"Why It Matters","paragraphs":["It helps keep the page grounded in visible-appearance evidence rather than over-strong marketing comparisons."]}],"source_type":"peer_reviewed","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/18498523/"}