---
title: Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/blanes-mira-2002-argireline
date_modified: 2026-05-17
date_reviewed: 2026-05-17
mcp_eligible: true
source_type: peer_reviewed
original_source_url: https://pubmed.ncbi.nlm.nih.gov/18498523/
evidence_sources: []
product_fact_sources: []
---

# Blanes-Mira 2002 — A synthetic hexapeptide with antiwrinkle activity

## Quick Summary

Foundational Argireline paper describing acetyl hexapeptide-3, proposed SNARE-complex interference, and a small topical wrinkle-depth study.

## What Studied

Reference used for Argireline, peptide, wrinkle, or product-fact context in this cosmetic skincare page.

## Main Findings

The source supports cautious appearance-focused language and does not justify injectable-equivalent claims for topical Argireline skincare.

## Why It Matters

It helps keep the page grounded in visible-appearance evidence rather than over-strong marketing comparisons.

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