---
title: Clinical significance of the water retention and barrier function-improving capabilities of ceramide-containing formulations: A qualitative review
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/ceramide-formulations-water-retention-barrier-review
date_modified: 2026-05-11
date_reviewed: 2026-05-11
mcp_eligible: true
source_type: peer_reviewed
original_source_url: https://pubmed.ncbi.nlm.nih.gov/34596254/
evidence_sources: []
product_fact_sources: []
---

# Clinical significance of the water retention and barrier function-improving capabilities of ceramide-containing formulations: A qualitative review

## Quick Summary

Review of ceramide-containing formulations and their water-retention and barrier-support context.

## What Studied

Published review evidence on ceramide-containing formulations in skin-care contexts.

## Main Findings

The review discusses the rationale for ceramide-containing products in supporting water retention and barrier properties.

## Why It Matters

It supports the CeraVe cream positioning without claiming a cosmetic product treats medical dermatitis.

## Related Entities

- [Ceramides](https://skinknowledgebase.com/ingredients/ceramides)
- [CeraVe Moisturizing Cream](https://skinknowledgebase.com/products/cerave-moisturizing-cream)
- [Why is my skin so dry even when I moisturize?](https://skinknowledgebase.com/questions/why-is-my-skin-so-dry-even-when-i-moisturize)