---
title: de Miranda 2021 — Hydrolyzed collagen systematic review and meta-analysis
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/demiranda-2021-hydrolyzed-collagen-meta-analysis
date_modified: 2026-05-20
date_reviewed: 2026-05-20
mcp_eligible: true
summary: de Miranda 2021 reviewed hydrolyzed collagen trials measuring hydration, elasticity, wrinkles, and firmness, supporting cautious oral-collagen context.
source_type: peer_reviewed
original_source_url: https://pubmed.ncbi.nlm.nih.gov/33742704/
evidence_sources: []
product_fact_sources: []
---

# de Miranda 2021 — Hydrolyzed collagen systematic review and meta-analysis

## Quick Summary

Systematic review and meta-analysis used for oral hydrolyzed collagen evidence on hydration, elasticity, wrinkles, and firmness-related measures.

## What Studied

Systematic review and meta-analysis of randomized controlled trials of oral hydrolyzed collagen supplementation and skin-aging outcomes.

## Main Findings

The review evaluated trials reporting skin wrinkles, hydration, elasticity, and firmness; public copy uses it as supportive but modest supplement evidence.

## Why It Matters

It anchors the oral-collagen evidence discussion while avoiding claims that drinks visibly reshape or structurally change skin.

## Related Entities

- [Can collagen drinks actually firm skin?](https://skinknowledgebase.com/questions/can-collagen-drinks-actually-firm-skin)