---
title: Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/hyaluronic-acid-different-molecular-weights
date_modified: 2026-05-11
date_reviewed: 2026-05-11
mcp_eligible: true
source_type: peer_reviewed
original_source_url: https://pubmed.ncbi.nlm.nih.gov/22052267/
evidence_sources: []
product_fact_sources: []
---

# Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment

## Quick Summary

Clinical study of topical hyaluronic-acid formulations with different molecular weights.

## What Studied

Topical HA formulation research in facial appearance context.

## Main Findings

The study evaluates HA formulations and skin-appearance endpoints, but it does not prove every HA serum fixes dry skin.

## Why It Matters

It helps frame HA as a hydration-support ingredient that often still needs a cream seal.

## Related Entities

- [Hyaluronic Acid](https://skinknowledgebase.com/ingredients/hyaluronic-acid)
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- [Why is my skin so dry even when I moisturize?](https://skinknowledgebase.com/questions/why-is-my-skin-so-dry-even-when-i-moisturize)