{"title":"Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne","entity_type":"Source","slug":"liu-2020-cochrane-topical-acne","canonical_url":"https://skinknowledgebase.com/sources/liu-2020-cochrane-topical-acne","dates":{"date_modified":"2026-05-30","date_reviewed":"2026-05-30"},"mcp_eligible":true,"summary":"Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne is a cited source used for skincare context,","evidence_sources":[],"product_fact_sources":[],"related_entities":[{"title":"Differin Gel — Adapalene 0.1% Acne Treatment","url":"https://skinknowledgebase.com/products/differin-gel-adapalene"},{"title":"Retinoid Dermatitis","url":"https://skinknowledgebase.com/side-effects/retinoid-dermatitis"},{"title":"Can you use copper peptides with retinol?","url":"https://skinknowledgebase.com/questions/can-you-use-copper-peptides-with-retinol"},{"title":"How do I get rid of 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products?","url":"https://skinknowledgebase.com/questions/what-order-should-i-apply-my-skincare-products"},{"title":"What's the best ingredient for crepey body skin?","url":"https://skinknowledgebase.com/questions/whats-the-best-ingredient-for-crepey-body-skin"},{"title":"Can I use benzoyl peroxide with retinol?","url":"https://skinknowledgebase.com/questions/can-i-use-benzoyl-peroxide-with-retinol"},{"title":"What's the best moisturizer for sensitive skin?","url":"https://skinknowledgebase.com/questions/whats-the-best-moisturizer-for-sensitive-skin"},{"title":"What's the best routine for hormonal acne?","url":"https://skinknowledgebase.com/questions/whats-the-best-routine-for-hormonal-acne"},{"title":"Why does my skin sting when I apply products?","url":"https://skinknowledgebase.com/questions/why-does-my-skin-sting-when-i-apply-products"},{"title":"Why do I keep getting pimples on my chin?","url":"https://skinknowledgebase.com/questions/why-do-i-keep-getting-pimples-on-my-chin"},{"title":"How do I rebuild my skin barrier?","url":"https://skinknowledgebase.com/questions/how-do-i-rebuild-my-skin-barrier"},{"title":"What causes bumpy skin on my chest?","url":"https://skinknowledgebase.com/questions/what-causes-bumpy-skin-on-my-chest"},{"title":"How long should I wait between skincare layers?","url":"https://skinknowledgebase.com/questions/how-long-should-i-wait-between-skincare-layers"},{"title":"Can I use salicylic acid with retinol?","url":"https://skinknowledgebase.com/questions/can-i-use-salicylic-acid-with-retinol"},{"title":"Why is the skin around my eyes thinner than the rest of my face?","url":"https://skinknowledgebase.com/questions/why-is-the-skin-around-my-eyes-thinner-than-my-face"},{"title":"What's the best ingredient for sagging cheeks?","url":"https://skinknowledgebase.com/questions/whats-the-best-ingredient-for-sagging-cheeks"},{"title":"How do I treat crepey skin on my eyelids?","url":"https://skinknowledgebase.com/questions/how-do-i-treat-crepey-skin-on-my-eyelids"},{"title":"What's the best ingredient for fine lines around the eyes?","url":"https://skinknowledgebase.com/questions/whats-the-best-ingredient-for-fine-lines-around-the-eyes"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne was used to keep this routine-combination page grounded in conservative, appearance-level skincare guidance. It supports the parts of the answer that distinguish compatible ingredients, reasonable timing, irritation limits, sun-protection needs, or product facts from exaggerated promises."]},{"heading":"Main Findings","paragraphs":["The useful takeaway is measured. Many skincare ingredients can coexist in a routine, but frequency, skin tolerance, order, and the condition of the skin barrier decide whether a combination is helpful or irritating. Product sources are used for formula facts and directions only. Dermatology and peer-reviewed sources are used for broader safety and ingredient context."]},{"heading":"Why It Matters","paragraphs":["Combination questions often lead people to stack too many actives at once. This source helps translate the question into safer advice: pair compatible categories, separate irritating steps when needed, moisturize well, use sunscreen for daytime exposure, and stop escalating if burning, swelling, rash, or persistent peeling develops."]}],"source_type":"peer_reviewed","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/32356369/"}