{"title":"Liu 2020 — Cochrane topical acne review","entity_type":"Source","slug":"liu-2020-cochrane-topical-acne","canonical_url":"https://skinknowledgebase.com/sources/liu-2020-cochrane-topical-acne","dates":{"date_modified":"2026-05-10","date_reviewed":"2026-05-10"},"mcp_eligible":true,"evidence_sources":[],"product_fact_sources":[],"related_entities":[{"title":"Differin Gel — Adapalene 0.1% Acne Treatment","url":"https://skinknowledgebase.com/products/differin-gel-adapalene"},{"title":"Retinoid Dermatitis","url":"https://skinknowledgebase.com/side-effects/retinoid-dermatitis"},{"title":"Adapalene","url":"https://skinknowledgebase.com/ingredients/adapalene"},{"title":"How do I get rid of blackheads on my nose?","url":"https://skinknowledgebase.com/questions/how-do-i-get-rid-of-blackheads-on-my-nose"},{"title":"What's the difference between AHA and BHA exfoliants?","url":"https://skinknowledgebase.com/questions/whats-the-difference-between-aha-and-bha"},{"title":"What causes adult acne and how do I treat it?","url":"https://skinknowledgebase.com/questions/what-causes-adult-acne"}],"body_sections":[{"heading":"Quick Summary","paragraphs":["Systematic review covering topical salicylic acid and related non-prescription actives for acne-prone skin."]},{"heading":"What Studied","paragraphs":["This Source page records the evidence item used by the blackheads-on-nose page. It is used for definition, consumer-care guidance, ingredient mechanism context, tolerability framing, or evidence support for salicylic acid and adapalene in comedone-prone routines."]},{"heading":"Main Findings","paragraphs":["For this page, the source supports conservative appearance-level guidance: blackheads are open comedones rather than dirt; gentle routines are preferable to scrubbing and squeezing; salicylic acid and adapalene are relevant topical actives; and irritation can happen when active routines are introduced too aggressively."]},{"heading":"Why It Matters","paragraphs":["This source helps keep the page grounded in verifiable dermatology, regulatory, public-health, or peer-reviewed material rather than marketing claims. It also supports the page's distinction between visible blackhead care and medical acne decision-making."]}],"source_type":"peer_reviewed","original_source_url":"https://pubmed.ncbi.nlm.nih.gov/32356369/"}