---
title: Souza 2013 — Haloxyl and periorbital hyperpigmentation
entity_type: Source
canonical_url: https://skinknowledgebase.com/sources/souza-2013-haloxyl-periorbital-hyperpigmentation
date_modified: 2026-05-11
date_reviewed: 2026-05-11
mcp_eligible: true
source_type: peer_reviewed
original_source_url: https://www.redalyc.org/articulo.oa?id=265526285003
evidence_sources: []
product_fact_sources: []
---

# Souza 2013 — Haloxyl and periorbital hyperpigmentation

## Quick Summary

A peer-reviewed comparative study that included 2 percent Haloxyl gel as one topical option for periorbital hyperpigmentation and dark-circle appearance.

## What Studied

Eighty patients with periorbital hyperpigmentation were assigned to topical 2.5 percent thioglycolic acid, 2 percent hydroquinone, 2 percent Haloxyl gel, or serial 10 percent thioglycolic acid peels.

## Main Findings

The abstract reports the best results in the thioglycolic acid and hydroquinone groups, with the Haloxyl group slightly inferior, possibly because of the low concentration used. The article also describes Haloxyl as a composition involving matrikines, chrysin, and N-Hydroxysuccinimide.

## Why It Matters

This source supports cautious, appearance-only mention of Haloxyl in dark-circle routines. It does not justify medical treatment language or promises that an eye product removes dark circles.

## Related Entities

- [Haloxyl](https://skinknowledgebase.com/ingredients/haloxyl)
- [Dark Circles](https://skinknowledgebase.com/concerns/dark-circles)
- [How do I get rid of dark circles under my eyes?](https://skinknowledgebase.com/questions/how-do-i-get-rid-of-dark-circles-under-my-eyes)