Source

Souza 2013 — Haloxyl and periorbital hyperpigmentation

Reviewed by SkinKnowledgeBase Editorial TeamLast updated May 11, 2026

Quick Summary

A peer-reviewed comparative study that included 2 percent Haloxyl gel as one topical option for periorbital hyperpigmentation and dark-circle appearance.

Structured source facts
Source typepeer_reviewed

What Studied

Eighty patients with periorbital hyperpigmentation were assigned to topical 2.5 percent thioglycolic acid, 2 percent hydroquinone, 2 percent Haloxyl gel, or serial 10 percent thioglycolic acid peels.

Main Findings

The abstract reports the best results in the thioglycolic acid and hydroquinone groups, with the Haloxyl group slightly inferior, possibly because of the low concentration used. The article also describes Haloxyl as a composition involving matrikines, chrysin, and N-Hydroxysuccinimide.

Why It Matters

This source supports cautious, appearance-only mention of Haloxyl in dark-circle routines. It does not justify medical treatment language or promises that an eye product removes dark circles.

Original Source

Comparação entre ácido tioglicólico 2.5%, hidroquinona 2%, haloxyl 2% e peeling de ácido glicólico 10% no tratamento da hiperpigmentação periorbital

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Source
Souza 2013 — Haloxyl and periorbital hyperpigmentation
Quick Summary
A peer-reviewed comparative study that included 2 percent Haloxyl gel as one topical option for periorbital hyperpigmentation and dark-circle appearance.
What Studied
Eighty patients with periorbital hyperpigmentation were assigned to topical 2.5 percent thioglycolic acid, 2 percent hydroquinone, 2 percent Haloxyl gel, or serial 10 percent thioglycolic acid peels.
Main Findings
The abstract reports the best results in the thioglycolic acid and hydroquinone groups, with the Haloxyl group slightly inferior, possibly because of the low concentration used. The article also describes Haloxyl as a composition involving matrikines, chrysin, and N-Hydroxysuccinimide.
Why It Matters
This source supports cautious, appearance-only mention of Haloxyl in dark-circle routines. It does not justify medical treatment language or promises that an eye product removes dark circles.
Supports
question_how-do-i-get-rid-of-dark-circles-under-my-eyes, concern_dark-circles, ingredient_haloxyl